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Disse bivirkningene omfatter blant annet nyreskade, diabetes og hjerte- og karsykdom Sirolimus kan endre fenotypisk invasive celler til ikke-invasive celler og redusere tumorvekst i mus Everolimus har dokumentert god effekt mot flere former for kreft hos ikke-transplanterte pasienter, bl.

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This paper provides a brief overview of the assumed underlying mechanisms. The paper builds on relevant articles daing studies identified in the course of many years of interest in immunopharmacology and skin cancer after organ transplantation. Reduced immunological tumour surveillance as a result of chronic grahis has long been assumed to underlie the increased risk of skin cancer after organ transplants. Recent studies indicate that immunosuppressive drugs may also have specific carcinogenic effects. Aziatropine, which inhibits proliferation of lymphocytes, increases oxidative DNA damage caused by UV radiation.

Ciclosporin and tacrolimus, which have an immunosuppressive effect by inhibiting calcineurin, promote malignant phenotypes in cell culture and tumour growth in mouse models. Calcineurin has proved to be necessary in order for p53 protein to have a protective effect against skin cancer. A relatively new class of immunosuppressive drugs, mTOR inhibitors, have antineoplastic properties and are associated with less risk of skin cancer. A number of randomised studies are currently in progress to see whether mTOR inhibitors can reduce the risk of skin cancer after organ transplantation.

Immunosuppressive drugs contribute to skin cancer after organ transplantation, either as a result of immunosuppression or through specific carcinogenic mechanisms. Immunosuppressive drugs with antineoplastic properties are now starting to be used. Skin cancers after organ transplantation. N Engl J Med ; Organ transplantation and skin cancer: Exp Dermatol ; Immunsuppressive medikamenter ved organtransplantasjon. Cancer Treat Res ; The epidemiology of skin cancer in organ transplant recipients. Otley CC, Stasko T, red. Skin disease in organ transplantation. Cambridge University Press, The secret sun charles manson and uncle sam s secret. Interviews archive at tadias magazine.

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